We are focusing on design and synthesis of organic compounds and nanoparticles for various biomedical applications. Our research interests are MRI CAs, in vitro diagnosis, drug delivery, diseases treatment and fluorine-19 MRI probes for bioimaging.

Publications            2025      2024      2023      2022      2021      Earlier       Patents

2025

    Visualizing Enterohepatic Circulation In Vivo by Sensitive 19F MRI with a Fluorinated Ferrous Chelate-Based Small Molecule Probe
    Lingxuan Li, Ao Li, Junjie Wang, Juan Shao, Huijie Zhou, Zixiong Peng, Hongyu Lin* and Jinhao Gao*
    Biomaterials 2025, 317, 123073. [Full Text Link]

    Sensitive Multichannel 19F Magnetic Resonance Imaging Enabled by Paramagnetic Fluorinated Ionic Liquid-Based Probes
    Limin Chen, Yuhang Jiang, Nan Xiong, Yifan Fan, Hongyu Lin* and Jinhao Gao*
    ACS Nano 2025, 19, 9061-9069. [Full Text Link]

    Super-multiplexed imaging and coding in the range of radio frequency
    Yuhang Jiang, Yifan Fan, Limin Chen, Hongyu Lin* and Jinhao Gao*
    Nat. Commun. 2025, 16, 2567. [Full Text Link]

    Small Fluorinated Aromatic Molecule-based Radiofrequency Identification Tags Enabled by Stepwise Tuning of Nuclear Shielding
    Yuhang Jiang, Limin Chen, Junjie Wang, Hongyu Lin* and Jinhao Gao*
    Angew. Chem. Int. Ed. 2025, e202506846. [Full Text Link]

2024

    Fluorinated 1,7-DO2A-Based Iron(II) Complexes as Sensitive 19F MRI Molecular Probes for Visualizing Renal Dysfunction in Living Mice
    Lingxuan Li, Chuankai Chen, Yifan Bu, Junjie Wang, Juan Shao, Ao Li*, Hongyu Lin* and Jinhao Gao*
    Anal. Chem. 2024, 96, 10827-10834. [Full Text Link]

    Copper-Based Fluorinated MOFs for Activatable Multicolor 19F MRI and Regulated Cell Death-Promoting Therapy of Tumor
    Yifan Fan, Xiaoqin Chi, Jingyan Li, Yuanxi Zheng, Limin Chen, Yuhang Jiang, Zhenyu Yin, Hongyu Lin* and Jinhao Gao*
    Nano Today 2024, 57, 102364. [Full Text Link]

2023

    Glycan Metabolic Fluorine Labeling for in Vivo Visualization of Tumor Cells and in Situ Assessment of Glycosylation Variations
    Dongxia Chen, Yaying Lin, Yifan Fan, Lingxuan Li, Chenlei Tan, Junjie Wang, Hongyu Lin* and Jinhao Gao*
    Angew. Chem. Int. Ed. 2023, 62, e202313753. [Full Text Link]

    Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice
    Dongxia Chen, Junnan Guo, Ao Li, Chengjie Sun, Huibin Lin, Hongyu Lin*, Chaoyong Yang*, Wei Wang* and Jinhao Gao*
    Sci. Adv. 2023, 9, eabg6808. [Full Text Link]

    Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex 19F MRI in Living Mice
    Xiaoxue Tang, Ao Li, Cuicui Zuo, Xing Liu, Xiangjie Luo, Limin Chen, Lingxuan Li, Hongyu Lin* and Jinhao Gao*
    ACS Nano 2023, 17, 5014-5024. [Full Text Link]

    Small Molecule Probes for 19F Magnetic Resonance Imaging
    Ao Li, Xiangjie Luo, Dongxia Chen, Lingxuan Li, Hongyu Lin* and Jinhao Gao*
    Anal. Chem. 2023, 95, 70-82. [Full Text Link]

    Fluorinated Iron Metal–Organic Frameworks for Activatable 19F Magnetic Resonance Imaging and Synergistic Therapy of Tumors
    Yifan Fan, Dongxia Chen, Limin Chen, Kun Liu, Yuanxi Zheng, Lingxuan Li, Jingyan Li, Hongyu Lin* and Jinhao Gao*
    Nano Lett. 2023, 23, 11989-11998. [Full Text Link]

    Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation
    Xiangjie Luo, Hui Xiong, Yuhang Jiang, Yifan Fan, Cuicui Zuo, Dongxia Chen, Limin Chen, Hongyu Lin and Jinhao Gao*
    Bioconjugate Chem. 2023, 34, 7, 1316-1326. [Full Text Link]

    Constructing sequence-controlled heterolayered dendritic lanthanide chelates via a one-pot strategy using orthogonal chemistry
    Zhaoxuan Yang, Haojin Lin, Yaying Lin, Jinzhi Wang, Yifan Bu, Hongyu Lin* and Jinhao Gao*
    Chem. Commun. 2023, 59, 6195-6198. [Full Text Link]

    Nanoparticle-Based Activatable MRI Probes for Disease Imaging and Monitoring
    Yifan Fan, Limin Chen, Yuanxi Zheng, Ao Li, Hongyu Lin* and Jinhao Gao*
    Chem. Biomed. Imaging 2023, 1, 192-204. [Full Text Link]

    Multicolor 19F magnetic resonance imaging: A promising medicaltechnique for in vivo visualization of multiple biological targets
    Yuhang Jiang, Xiangjie Luo, Limin Chen, Hongyu Lin* and Jinhao Gao*
    Fundamental Res. 2023, 3, 529-533. [Full Text Link]

2022

    19F Barcoding Enables Multiplex Detection of Biomarkers Associated with Organ Injury and Cancer
    Xiangjie Luo, Bilun Kang, Xiaoqin Chi, Hui Xiong, Dongxia Chen, Yifan Fan, Lingxuan Li, Limin Chen, Ao Li, Jinhao Gao and Hongyu Lin*
    Angew. Chem. Int. Ed. 2022, 61, e202211189. [Full Text Link]

    Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T1 Contrast Enhancement for Magnetic Resonance Imaging
    Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai*, Hongyu Lin* and Jinhao Gao*
    Nano Lett. 2022, 22, 3219-3227. [Full Text Link]

    Bio-orthogonal Metabolic Fluorine Labeling Enables Deep-Tissue Visualization of Tumor Cells In Vivo by 19F Magnetic Resonance Imaging
    Dongxia Chen, Yaying Lin, Ao Li, Xiangjie Luo, Chaoyong Yang, Jinhao Gao* and Hongyu Lin*
    Anal. Chem. 2022, 94, 16614-16621. [Full Text Link]

    An Activatable 19F MRI Molecular Probe for Sensing and Imaging of Norepinephrine
    Lingxuan Li, Ao Li, Yaying Lin, Dongxia Chen, Bilun Kang, Hongyu Lin* and Jinhao Gao*
    ChemistryOpen 2022, 11, e202200110. [Full Text Link]

    Sequence-controlled heterolayered lanthanide-complex dendritic architectures constructed from modular Ln-DOTA derivatives
    Zhaoxuan Yang, Chengjie Sun, Yaying Lin, Haojin Lin, Jinhao Gao* and Hongyu Lin*
    Cell Rep. Phys. Sci. 2022, 3, 100950. [Full Text Link]

    Multinuclear Mn(II) united-DOTA complexes with enhanced inertness and high MRI contrast ability
    Chengjie Sun, Zhaoxuan Yang, Peng Wu, Xiangjie Luo, Kun Liu, Binju Wang, Hongyu Lin* and Jinhao Gao*
    Cell Rep. Phys. Sci. 2022, 3, 100920. [Full Text Link]

    Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug
    Zhaoxuan Yang, Xiangjie Luo, Yaying Lin, Jiaqi Huang, Hongyu Lin* and Jinhao Gao*
    ACS Chem. Biol. 2022, 17, 762-767. [Full Text Link]

    Boronate-based 19F NMR/MRI Molecular Probe for Activatable Deep-tissue Imaging of Reactive Oxygen Species
    Ao Li, Lingxuan Li, Cuicui Zuo, Chuankai Chen, Yifan Fan, Yifan Bu, Hongyu Lin* and Jinhao Gao*
    Chem. J. Chin. Univ. 2022, 43, 20220545. [Full Text Link]

    Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T1-Weighted Contrast-Enhanced Brain Imaging
    Ruixue Wei*, Kun Liu, Ke Zhang, Yifan Fan, Hongyu Lin* and Jinhao Gao
    ACS Appl. Mater. Interfaces 2022, 14, 3784-3791. [Full Text Link]

    Recent Advances in Engineering Iron Oxide Nanoparticles for Effective Magnetic Resonance Imaging
    Zhenghuan Zhao, Muyao Li, Jie Zeng, Linlin Huo, Kun Liu, Ruixue Wei, Kaiyuan Ni and Jinhao Gao*
    Bioact. Mater. 2022, 12, 214-245. [Full Text Link]

2021

    Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects
    Hongyu Lin, Xiaoxue Tang, Ao Li and Jinhao Gao*
    Adv. Mater. 2021, 33, 2005657. [Full Text Link]

    Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy
    Xiangjie Luo, Xuanqing Gong, Liyun Su, Hongyu Lin, Zhaoxuan Yang, Xiaomei Yan and Jinhao Gao*
    Angew. Chem. Int. Ed. 2021, 60, 1403-1410. [Full Text Link]

    Redox-Activated Contrast-Enhanced T1 -Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver
    Kun Liu, Bilun Kang, Xiangjie Luo, Zhaoxuan Yang, Chengjie Sun, Ao Li, Yifan Fan, Xiaoyuan Chen, Jinhao Gao* and Hongyu Lin*
    ACS Nano 2021, 15, 17831-17841. [Full Text Link]

    Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury
    Ao Li, Xiangjie Luo, Lingxuan Li, Dongxia Chen, Xing Liu, Zhaoxuan Yang, Lijiao Yang, Jinhao Gao* and Hongyu Lin*
    Anal. Chem. 2021, 93, 16552-16561. [Full Text Link]

    Imaging Beyond Seeing: Early Prognosis of Cancer Treatment
    Changrong Shi, Zijian Zhou*, Hongyu Lin* and Jinhao Gao*
    Small Methods 2021, 3, 2001025. [Full Text Link]

    A Camptothecin Prodrug Induces Mitochondria-mediated Apoptosis in Cancer Cells with Cascade Activations
    Xiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin* and Jinhao Gao*
    Chem. Commun. 2021, 57, 11033-11036. [Full Text Link]

    Deep-tissue Real-time Imaging of Drug-induced Liver Injury with Peroxynitrite-responsive 19F MRI Nanoprobes
    Ao Li, Lingxuan Li, Xing Liu, Dongxia Chen, Yifan Fan, Hongyu Lin* and Jinhao Gao*
    Chem. Commun. 2021, 57, 9622-9625. [Full Text Link]

    Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1α Downregulation for Tumor Treatment
    Xiangjie Luo, Ao Li, Xiaoqin Chi, Yaying Lin, Xing Liu, Lifan Zhang, Xinhui Su, Zhenyu Yin, Hongyu Lin* and Jinhao Gao*
    Bioconjugate Chem. 2021, 32, 983-990. [Full Text Link]

2020

2019

    Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging
    Zijian Zhou; Lijiao Yang; Jinhao Gao* and Xiaoyuan Chen*
    Adv. Mater. 2019, 31, 1804567. [Full Text Link]

    Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery
    Ruixue Wei; Xuanqing Gong; Hongyu Lin; Ke Zhang; Ao Li; Kun Liu; Hong Shan; Xiaoyuan Chen and Jinhao Gao*
    Nano Lett. 2019, 19, 5394-5402. [Full Text Link]

    Pro-Death or Pro-Survival: Contrasting Paradigms on Nanomaterial-Induced Autophagy and Exploitations for Cancer Therapy
    Yunjiao Zhang*; Li Zhang; Jinhao Gao* and Longping Wen*
    Acc. Chem. Res. 2019, 52, 3164-3176. [Full Text Link]

    Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods
    Lijiao Yang; Chengjie Sun; Hongyu Lin; Xuanqing Gong; Tiantian Zhou; Wen-Ting Deng; Zhong Chen and Jinhao Gao*
    Chem. Mater. 2019, 31, 1381-1390. [Full Text Link]

    A fluorinated bihydrazide conjugate for activatable sensing and imaging of hypochlorous acid by 19F NMR/MRI
    Ao Li; Xiaoxue Tang; Xuanqing Gong; Hongming Chen; Hongyu Lin* and Jinhao Gao*
    Chem. Commun. 2019, 55, 12455-12458. [Full Text Link]

    A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy
    Zhaoxuan Yang; Hongyu Lin; Jiaqi Huang; Ao Li; Chengjie Sun; Jonathan Richmond; and Jinhao Gao*
    Chem. Commun. 2019, 55, 4546-4549. [Full Text Link]

    Surface Engineering to Boost the Performance of Nanoparticle‐Based T1 Contrast Agents
    Hongyu Lin*; Kun Liu and Jinhao Gao*
    Eur. J. Inorg. Chem. 2019, 3801-3809. [Full Text Link]

    An Albumin-Binding T1T2 Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging
    Zijian Zhou; Ruiliang Bai; Zhantong Wang; Henry Bryant; Lixin Lang; Jinhao Gao* and Xiaoyuan Chen*
    Bioconjugate Chem. 2019, 30, 1821-1829. [Full Text Link]

2018

2017

    Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability
    Lijiao Yang; Lengceng Ma; Jingyu Xin; Ao Li; Chengjie Sun; Ruixue Wei; Bin W. Ren; Zhong Chen; Hongyu Lin; and Jinhao Gao*
    Chem. Mater. 2017, 29, 3038-3047. [Full Text Link]

    Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease 2
    Xianglong Zhu; Hongyu Lin; Lirong Wang; Xiaoxue Tang; Lengceng Ma; Zhong Chen; and Jinhao Gao*
    ACS Appl. Mater. Interfaces 2017, 9, 21688-21696. [Full Text Link]

2016

    Cation exchange of anisotropic-shaped magnetite nanoparticles generates high-relaxivity contrast agents for liver tumor imaging
    Zhao, Z. H.; Chi, X. Q.; Yang, L. J.; Yang, R.; Ren, B. W.; Zhu, X. L.; Zhang, P.; Gao, J. H.*
    Chem. Mater. 2016, 28, 3497-3506. [Full Text Link]

    Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells
    Liu H. Y.; Zhang Z. J.; Chi X. Q.; Zhao Z. H.; Huang D .T.; Jin J. B.; Gao, J. H.*
    Sci. Rep. 2016, 6, 31009. [Full Text Link]

2011-2015
2006-2010
Patents

    1.一种装载砷剂及其制备方法与应用。授权日:2018-4-24
    2.一种以碳基材料为支架的磁共振造影剂及其制备方法。授权日: 2017-03-01
    3.一种核壳结构的金属/铁氧化物纳米材料及其制备方法。授权日: 2015-09-09
    4.一种装载砷剂的抗癌纳米药物及其制备方法。授权日:2014-04-06
    5.一种具有立方结构的金聚集体纳米材料及其合成方法。授权日:2014-01-10