We are working on design and synthesis of organic compounds and nanoparticles for various biomedical applications. MRI contrast agents, in vitro diagnosis, drug delivery, cancer diagnosis and treatment, and nano-bio interactions are our research subjects.

林泓域/Hongyu Lin
教授、博士生导师
电话:86-592-2181963
办公室:卢嘉锡楼542室
电子邮箱:hylin007(AT)xmu.edu.cn

个人简历:

南京大学化学化工学院 理学学士(2003-2007)

美国Brandeis University化学系 理学博士(2007-2012)

Brandeis University Career Development Fellowship (2007-2012)

美国Cornell University化学与化学生物学系 博士后(2013-2015)

厦门大学化学化工学院化学生物学系 副教授(2016-2024)

厦门大学化学化工学院化学生物学系 教授、博士生导师(2024-至今)

研究兴趣:

分子磁共振造影剂

分子诊疗试剂

分子探针

近期主要代表论著:

(1) Hongyu Lin; Xiaoxue Tang; Ao Li; and Jinhao Gao* Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 2005657. 

(2) Xiangjie Luo; Xuanqing Gong; Liyun Su; Hongyu Lin; Zhaoxuan Yang; Xiaomei Yan; and Jinhao Gao* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410. 

(3) Xiaoxue Tang; Xuanqing Gong; Jiang Ming; Dongxia Chen; Hongyu Lin*and Jinhao Gao* Fluorinated Gadolinium Chelate-Grafted Nanoconjugates for Contrast-Enhanced T1-Weighted 1H and pH-Activatable 19F Dual-Modal MRI. Anal. Chem. 2020, 92, 16293-16300.

(4) Xiaoqin Chi; Kun Liu; Xiangjie Luo; Zhenyu Yin; Hongyu Lin* and Jinhao Gao* Recent advances of nanomedicines for liver cancer therapy.J. Mater. Chem.B 2020, 8, 3747-3771.

(5) Chengjie Sun; Hongyu Lin; Xuanqing Gong; Zhaoxuan Yang; Yan Mo; Xiaoyuan Chen and Jinhao Gao* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.

(6) Hongming Chen; Xiaoxue Tang; Xuanqing Gong; Dongxia Chen; Ao Li; Chengjie Sun; Hongyu Lin* and Jinhao Gao* Reversible redox-responsive 1H/19F MRI molecular probes. Chem. Commun. 2020, 56, 4106-4109.

(7) Ao Li; Xiaoxue Tang; Xuanqing Gong; Hongming Chen; Hongyu Lin* and Jinhao Gao* A fluorinated bihydrazide conjugate for activatable sensing and imaging of hypochlorous acid by 19F NMR/MRI. Chem. Commun. 2019, 55, 12455-12458.

(8) Zhaoxuan Yang; Hongyu Lin; Jiaqi Huang; Ao Li; Chengjie Sun; Jonathan Richmond; and Jinhao Gao* A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy. Chem. Commun., 2019, 55 , 4546-4549.

(9) Hongyu Lin*; Kun Liu and Jinhao Gao* Surface Engineering to Boost the Performance of Nanoparticle‐Based T1 Contrast Agents. Eur. J. Inorg. Chem. 2019, 3801-3809.

(10) Lijiao Yang; Chengjie SunHongyu Lin; Xuanqing Gong; Tiantian Zhou; Wen-Ting Deng; Zhong Chen and Jinhao Gao* Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods. Chem. Mater. 2019, 31, 1381-1390.

(11). Lirong Wang; Hongyu Lin; Lingceng Ma; Jianbin Jin; Taipeng Shen; Ruixue Wei; Xiaomin Wang; Hua Ai; Zhong Chen; and  Jinhao Gao* Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Nanoscale 2017, 9, 4516-4523.

(12). Xianglong Zhu; Hongyu Lin; Lirong Wang; Xiaoxue Tang; Lengceng Ma; Zhong Chen; and Jinhao Gao* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Appl. Mater. Interfaces, 2017, 9 , 21688–21696.

(13). Lirong Wang;  Hongyu Lin;  Lengceng Ma; Chengjie Sun; Jiaqi Huang;  Ao Li; Tian Zhao; Zhong Chen; and Jinhao Gao* Geometrical confinement directed albumin-based nanoprobes as enhanced T1 contrast agents for tumor imaging. J. Mater. Chem.B 2017, 5, 8004-8012.

(14). Lin, H.-Y.; Haegele, J. A.; Disare, M. T.; Lin, Q.; Aye, Y. “A Generalizable Platform for Interrogating Target- and Signal-Specific Consequences of Electrophilic Modifications in Redox-Dependent Cell Signaling” J. Am. Chem. Soc. 2015, 137, 6232-6244.

(15). Parvez, S.; Fu, Y.; Li, J.; Long, M. J. C.;Lin, H.-Y.; Lee, D. K.; Hu, G.S.; Aye, Y. “Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response” J. Am. Chem. Soc. 2015, 137, 10-13.