教授、博士生导师
电话：86-592-2180278
传真：86-592-2189959
办公室：卢嘉锡楼528室
电子邮箱：jhgao(AT)xmu.edu.cn
学士（南京大学 2004）
博士（香港科技大学 2008）
博士后（斯坦福大学 2010）
厦门大学教授，博士生导师（2010.6-至今）
厦门大学化学生物学系主任（2018.9-至今）
香港青年科学家奖(2007)，教育部“新世纪优秀人才支持计划”（2010），福建省“闽江学者”特聘教授（2011），国家基金委优秀青年科学基金项目资助（2012），福建省杰出青年科学基金资助（2012），福建省青年拔尖创新人才（2014），中国化学会青年化学奖（2014），国家基金委杰出青年科学基金项目资助（2021）。
研究兴趣：功能性有机分子及纳米颗粒的设计合成及其临床应用；对多模式，高分辨的磁共振成像方式的探索;联药合成及体内外肿瘤诊断治疗等。
近期主要代表论著：
(1) Dongxia Chen, Junnan Guo, Ao Li, Chengjie Sun, Huibin Lin, Hongyu Lin*, Chaoyong Yang*, Wei Wang* and Jinhao Gao* Metabolic fluorine labeling and hotspot imaging of dynamic gut microbiota in mice. Sci. Adv. 2023, 9, eabg6808.
(2) Xiaoxue Tang, Ao Li, Cuicui Zuo, Xing Liu, Xiangjie Luo, Limin Chen, Lingxuan Li, Hongyu Lin* and Jinhao Gao* Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex 19F MRI in Living Mice. ACS Nano 2023, 17, 5014-5024.
(3) Ao Li, Xiangjie Luo, Dongxia Chen, Lingxuan Li, Hongyu Lin* and Jinhao Gao* Small Molecule Probes for 19F Magnetic Resonance Imaging. Anal. Chem. 2023, 95, 70–82.
(4) Xiangjie Luo, Bilun Kang, Xiaoqin Chi , Hui Xiong, Dongxia Chen, Yifan Fan, Lingxuan Li, Limin Chen, Ao Li, Jinhao Gao and Hongyu Lin* 19F Barcoding Enables Multiplex Detection of Biomarkers Associated with Organ Injury and Cancer. Angew. Chem. Int. Ed. 2022, 61, e202211189.
(5) Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai*, Hongyu Lin* and Jinhao Gao* Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T1 Contrast Enhancement for Magnetic Resonance Imaging. Nano Lett. 2022, 22, 3219-3227.
(6) Dongxia Chen, Yaying Lin, Ao Li, Xiangjie Luo, Chaoyong Yang, Jinhao Gao* and Hongyu Lin* Bio-orthogonal Metabolic Fluorine Labeling Enables Deep-Tissue Visualization of Tumor Cells In Vivo by 19F Magnetic Resonance Imaging. Anal. Chem. 2022, 94, 16614–16621.
(7) Hongyu Lin; Xiaoxue Tang; Ao Li; and Jinhao Gao* Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living Subjects. Adv. Mater. 2021, 33, 2005657.
(8) Xiangjie Luo; Xuanqing Gong; Liyun Su; Hongyu Lin; Zhaoxuan Yang; Xiaomei Yan; and Jinhao Gao* Activatable Mitochondria-Targeting Organoarsenic Prodrugs for Bioenergetic Cancer Therapy. Angew. Chem. Int. Ed. 2021, 60, 1403-1410.
(9) Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai*, Hongyu Lin* and Jinhao Gao* Redox-Activated Contrast-Enhanced T1 -Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano 2021, 15, 17831-17841.
(10)Ao Li, Xiangjie Luo, Lingxuan Li, Dongxia Chen, Xing Liu, Zhaoxuan Yang, Lijiao Yang, Jinhao Gao* and Hongyu Lin* Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury. Anal. Chem. 2021, 93, 16552-16561.
(11) Xianglong Zhu; Xiaoxue Tang; Hongyu Lin; Saige Shi; Hehe Xiong; Qiuju Zhou; Ao Li; Qiaoyang Wang; Xiaoyuan Chen and Jinhao Gao* A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological Targets. Chem. 2020, 6, 1134-1148.
(12) Xiaoxue Tang; Xuanqing Gong; Jiang Ming; Dongxia Chen; Hongyu Lin*and Jinhao Gao* Fluorinated Gadolinium Chelate-Grafted Nanoconjugates for Contrast-Enhanced T1-Weighted 1H and pH-Activatable 19F Dual-Modal MRI. Anal. Chem. 2020, 92, 16293-16300.
(13) Chengjie Sun; Hongyu Lin; Xuanqing Gong; Zhaoxuan Yang; Yan Mo; Xiaoyuan Chen and Jinhao Gao* DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators. J. Am. Chem. Soc. 2020, 142, 198-206.
(14) Xiaoxue Tang; Xuanqing Gong; Ao Li; Hongyu Lin; Chenyu Peng; Xianzhong Zhang; Xiaoyuan Chen and Jinhao Gao* Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification. Nano Lett. 2020, 20, 363-371.
(15) Ruixue Wei; Xuanqing Gong; Hongyu Lin; Ke Zhang; Ao Li; Kun Liu; Hong Shan; Xiaoyuan Chen and Jinhao Gao* Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery. Nano Lett. 2019, 19, 5394-5402.
(16) Lijiao Yang; Chengjie Sun; Hongyu Lin; Xuanqing Gong; Tiantian Zhou; Wen-Ting Deng; Zhong Chen and Jinhao Gao* Sensitive Contrast-Enhanced Magnetic Resonance Imaging of Orthotopic and Metastatic Hepatic Tumors by Ultralow Doses of Zinc Ferrite Octapods. Chem. Mater. 2019, 31, 1381-1390.
(17) Zijian Zhou; Lijiao Yang; Jinhao Gao* and Xiaoyuan Chen* Structure-Relaxivity Relationships of Magnetic Nanoparticles for Magnetic Resonance Imaging. Adv. Mater. 2019, 31, 1804567
(18) Lijiao Yang; Zhenyu Wang; Lengceng Ma; Ao Li; Jingyu Xin; Ruixue Wei; Hongyu Lin.; Ruifang Wang; Zhong Chen; and Jinhao Gao* The Roles of Morphology on the Relaxation Rates of Magnetic Nanoparticles. ACS Nano 2018, 12, 4605-4614.
(19) Lirong Wang; Hongyu Lin; Xiaoqin Chi; Chengjie Sun; Jiaqi Huang; Xiaoxue Tang; Hongming Chen; Xiangjie Luo; Zhenyu Yin; and Jinhao Gao* A Self‐Assembled Biocompatible Nanoplatform for Multimodal MR/Fluorescence Imaging Assisted Photothermal Therapy and Prognosis Analysis. Small 2018, 14, 1801612.
(20) Lijiao Yang; Lengceng Ma; Jingyu Xin; Ao Li; Chengjie Sun; Ruixue Wei; Bin W. Ren; Zhong Chen; Hongyu Lin; and Jinhao Gao* Composition Tunable Manganese Ferrite Nanoparticles for Optimized T2 Contrast Ability. Chem. Mater. 2017, 29, 3038–3047.
(21) Zhao, Z. H.; Chi, X. Q.; Yang, L. J.; Yang, R.; Ren, B. W.; Zhu, X. L.; Zhang, P.; Gao, J. H.*Cation exchange of anisotropic-shaped magnetite nanoparticles generates high-relaxivity contrast agents for liver tumor imaging. Chem. Mater. 2016, 28,3497-3506.
(22) Zhou, Z. J.; Wu, C. Q.; Liu, H. Y.; Zhu, X. L.; Zhao, Z. H.; Wang, L. R.; Xu, Y.; Ai, H.; Gao, J. H.* Surface and Interfacial Engineering of Iron Oxide Nanoplates for Highly Efficient Magnetic Resonance Angiography. ACS Nano 2015, 9, 3012-3022.
(23) Zhao, Z. H.; Wang, X. M.; Zhang, Z. J.; Zhang, H.; Liu, H. Y.; Zhu, X. L.; Li, H.; Chi, X. Q.; Yin, Z. Y.; Gao, J. H.* Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T1 Imaging. ACS Nano 2015, 9, 2749-2759.
(24) Zhu, X. L.; Hu, J; Zhao, Z. H.; Sun, M. J.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Kinetic and Sensitive Analysis of Tyrosinase Activity Using Electron Transfer Complexes: In Vitro and Intracellular Study. Small 2015, 11, 862-870.
(25) Zhou, Z. J.; Zhu, X.; Wu, D.; Chen, Q.; Huang, D.; Sun, C.; Xin, J.; Ni, K.; Gao, J. H.* Anisotropic Shaped Iron Oxide Nanostructures: Controlled Synthesis and Proton Relaxation Shortening Effects. Chem. Mater. 2015, 27, 3505-3515.
(26) Zhu, X.; Chi, X.; Chen, J.; Wang, L.; Wang, X.; Chen, Z.; Gao, J. H.* Real-Time Monitoring in Vivo Behaviors of Theranostic Nanoparticles by Contrast-Enhanced T1 Imaging. Anal. Chem. 2015, 87, 8941-8948.
(27) Zhou, Z. J.; Zhao, Z. H.; Zhang, H.; Wang, Z. Y.; Chen, X. Y.; Wang, R. F.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.
(28) Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z.; Hu, J.; Chi, X.; Ni, K.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-performance T2 Contrast Agents for Magnetic Resonance Imaging. Nature Commun. 2013, 4, 2266.
(29) Zhou, Z. J.; Wang, L. R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhan, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-oxide-based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.
(30) Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.
(31) Chi, X. Q.; Huang, D.T.; Zhao, Z. H.; Zhou, Z. J.; Yin, Z. Y.; Gao, J. H.* Nanoprobes for In Vitro Diagnostics of Cancer and Infectious Diseases. Biomaterials 2012, 33, 189-206.
(32) Gao, J. H.; Chen, K.; Luong, R.; Bouley, D. M.; Mao, H.; Qiao, T.; Gambhir, S. S.; Cheng, Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Lett. 2012, 12, 281-286.
(33) Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.
(34) Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.
(35) Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.
(36) Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.
(37) Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.
(38) Gao, J. H.; Li, L. H.; Ho, P. L.; Mak, G. C.; Gu, H. W.; Xu, B.* Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood. Adv. Mater. 2006, 18, 3145-3148.
(39) Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.* Magnetic Dipolar Interaction Induced Self-Assembly Affords Wires of Cobalt Selenide Hollow Nanoscrystals. Angew. Chem. Int. Ed. 2006, 45, 1220-1223.